产品货号：
Z26520
中文名称：
SHP2/PTPN11抗体
英文名称：
Anti-SHP2/PTPN11 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SHP2/PTPN11 Antibody |
| 指标别名 | BPTP3;CFC;NS1;PTP 1D;PTP 2C;PTP2C;PTPN11;SH PTP2;SH PTP3;SHP 2;SHP2;SHPTP2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC-F,ICC,FCM |
| 基因名称 | PTPN11 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human SHP2(582-597aa RVYENVGLMQQQKSFR),different from the related rat and mouse sequences by one amino acid. |
| 实际分子量 | 68KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | PTPN11(Tyrosine-protein phosphatase non-receptor type 11),also known as protein-tyrosine phosphatase 1D(PTP-1D),protein-tyrosine phosphatase 2C(PTP-2C),TYROSINE PHOSPHATASE SHP2(SHP2),BPTP3,SH-PTP2,SHP-2,SH-PTP3,is an enzyme that in humans is encoded by the PTPN11 gene.PTPN11 is a member of the protein tyrosine phosphatase(PTP) family.The open reading frame consists of 1,779 nucleotides potentially encoding a protein of 593 amino acids with a predicted molecular mass of 68kD.PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth,differentiation,mitotic cycle,and oncogenic transformation.This PTP contains two tandem Src homology-2 domains,which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates.This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions,such as mitogenic activation,metabolic control,transcription regulation,and cell migration.Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. |
| Uniprot ID | Q06124 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | protein tyrosine phosphatase,non-receptor type 11 |
| 蛋白名全称 | Tyrosine-protein phosphatase non-receptor type 11 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in frozen section (IHC-F) 1:50～400 Immunocytochemistry in fixed cells(ICC) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells |
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